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Testi inediti di armonia pratica.pdf. Percorsi di armonia pratica.pdf.A generic method for the quantification of vertebral fracture in patients with diabetes mellitus: a comparative study with radiographic vertebral morphometry. Vertebral fractures (VF) are a hallmark of osteoporosis. We developed and validated a method for the semiautomatic quantification of VF in patient cohorts. Osteoporotic fractures are often accompanied by diabetes mellitus (DM). We therefore investigated whether diabetic patients are more prone to VF than non-diabetic patients. Forty-four women and 40 men were evaluated. Bone mineral density (BMD) was determined by DEXA in vivo, and trabecular microstructure was measured in vivo by quantitative backscatter electron imaging (QBEI). We used radiographic vertebral morphometry (RV) as a reference method for the semiautomatic quantification of VF. In each patient, we identified four regions of interest (ROIs) encompassing the vertebrae L1-L4, and fracture risk was estimated using previously published criteria. Mean bone mineral density (g/cm2) in women and men, respectively, was -0.48 ± 0.10 and -0.42 ± 0.11 at the lumbar spine, and 0.27 ± 0.04 and 0.25 ± 0.05 at the total hip. RV revealed VF in 29.2% of women and 28.6% of men. Both in the diabetic and the non-diabetic group, respectively, the highest number of ROIs with VF was identified at L1. Additionally, the number of ROIs with VF increased with increasing age (P = 0.002). Using the RV method, we identified the following fracture patterns in non-diabetic patients: lateral compression with sparing of the vertebral bodies or collapse with preservation of the spinal canal. The incidence of VF as assessed by RV was slightly higher in diabetic patients than in non-diabetic patients (50% vs. 29.2%, P = 0.09). Diabetes mellitus had no influence on the fracture pattern. Patients with VF had lower BMD than non-fractured patients. Vertebral morphometry can easily be performed in clinical practice. Its use in patient cohorts could identify patients at high risk of developing VF. Additionally, we show

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